A tool hosted in the European Union keeps your data under the GDPR and out of direct reach of extraterritorial access laws such as the US Cloud Act. It is the default choice for public bodies and any organisation handling sensitive data. US hosting stays very common and often ahead on features, but it means framing transfers since the Schrems II ruling. Multi-region, in turn, replicates your data across several continents for performance and resilience.
None of these options is bad in itself: it depends on what you store and your regulatory duties. A freelancer handling quotes does not face the same constraints as a clinic or an HR team. Open the region that matches your case, then compare the listings. Each tool states its reported hosting, its vendor and its GDPR compliance, so you can decide without guessing.
See also